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Schedule
| Date | Day of Week | Opponent | Location | Time | Result |
| August 23, 2012 | Thursday | Poplar Bluff | Away | 4 p.m. | -- |
| August 27, 2012 | Monday | Puxico | Home | 4 p.m. | -- |
| August 28, 2012 | Tuesday | Perryville | Home | 4 p.m. | -- |
| August 29, 2012 | Wednesday | Farmington | Home | 4 p.m. | -- |
| August 30-September 1, 2012 | Thursday-Saturday | Notre Dame Softball Fest | Away | TBA | -- |
| September 4, 2012 | Tuesday | Cape Central | Home | 4 p.m. | -- |
| September 5, 2012 | Wednesday | Kelly | Away | 4 p.m. | -- |
| September 6, 2012 | Thursday | Portageville | Home | 4 p.m. | -- |
| September 8, 2012 | Saturday | Chaffee Tournament | Away | TBA | -- |
| September 10, 2012 | Monday | Notre Dame | Home | 4 p.m. | -- |
| September 12, 2012 | Wednesday | East Prairie | Away | 4 p.m. | -- |
| September 13, 2012 | Thursday | Twin Rivers | Away | 4:30 p.m. | -- |
| September 17, 2012 | Monday | Jackson | Away | 4:30 p.m. | -- |
| September 19, 2012 | Wednesday | Fredericktown | Home | 4 p.m. | -- |
| September 20, 2012 | Thursday | Oran | Away | 4 p.m. | -- |
| September 24, 2012 | Monday | Scott City | Away | 4 p.m. | -- |
| September 25, 2012 | Tuesday | East Carter County | Home | 4 p.m. | -- |
| September 26, 2012 | Wednesday | Saxony Lutheran | Home | 4 p.m. | -- |
| September 27, 2012 | Thursday | Delta | Away | 4 p.m. | -- |
| September 28-29, 2012 | Friday-Saturday | Three Rivers JV Tournament | TRCC | TBA | -- |
| October 1, 2012 | Monday | Naylor | Away | 4:30 p.m. | -- |